Key Scientific Milestones

2015
PIR method enters formal development, study, and clinical trial research
First major peer-reviewed publication in International Journal of Molecular Sciences, co-authored with researchers from Pennington Biomedical Research Center (LSU), UC Irvine, UT Health Science Center, and Mercer University School of Medicine
2022
2023
Second peer-reviewed publication, "A Receptor Story", published in Int. J. Mol. Sci.
Additional publications including outcome studies and improved kidney function case studies (43% of chronic kidney disease patients showed improvement)
2024-2025
March 2025
New patent secured for Well Cell Global
Randomized clinical trials underway for further objective validation
May 2026

Published Research

Greenway, F., Loveridge, B., Grimes, R.M., Tucker, T.R., Alexander, M., Hepford, S.A., et al. (2022). "Physiologic Insulin Resensitization as a Treatment Modality for Insulin Resistance Pathophysiology." International Journal of Molecular Sciences, 23(3), 1884. doi: 10.3390/ijms23031884
Lewis, S.T., Greenway, F., Tucker, T.R., Alexander, M., Jackson, L.K., Hepford, S.A., Loveridge, B., Lakey, J.R.T. (2023). "A Receptor Story: Insulin Resistance Pathophysiology and Physiologic Insulin Resensitization's Role as a Treatment Modality." Int. J. Mol. Sci., 24(13), 10927. doi: 10.3390/ijms241310927
Villaverde, Z., Tucker, T., Hepford, S., Lakey, J., Hinman, R. (2021). "Improved Kidney Function Following Physiologic Insulin Resensitization Treatment Modality." J. Endocrinol. Disord.

Medical & Scientific Advisory Board

Scott assembled a world-class advisory board to guide Well Cell's scientific mission
Brian Loveridge
M.D., F.A.A.E.M., Emergency Medicine, Advisory Board - Co Chair
Stanley Lewis
M.D., M.P.H., Internal Medicine
Advisory Board Member,
Eselle Health – CEO
Medical & Scientific Advisory Board Member
Scott A. Hepford
Founder – CEO
Well Cell Global
Advisory Board Member
Frank Greenway
M.D., Medical Director & Professor Pennington Biomedical Research,
Advisory Board Member
Richard (Dick) B.
Marchase Ph.D., 
Professor Emeritus,
Chief Science Officer
Advisory Board – Co Chair
Plus physicians and nurse practitioners from family medicine, endocrinology, and emergency medicine

Clinical Results

76%
of Patients Showed Improvement**
24%
Stemmed Their Decline**
(Schull Institute, 2015)
41%
of Patients Reduced at Least One Medication**
43%
of CKD Patients Showed Kidney Function Improvement (2025)*
95%
of Patients Improved
Their Neuropathy**
380,000+
PIR Treatments Administered Globally
PIR has been shown to help address neuropathy, diabetic ulcers, nephropathy, and retinopathy
Research supported in part
by NIH funding

(1 U54 GM104940 from NIGMS)
*Villaverde Z, Hinman RH II, Grimes RM. Physiologic insulin resensitization lowers cost in patients with diabetes and kidney disease. Am J Manag Care. 2025;31(1):294-297.
**Schull Institute – Insulin Infusion Therapy on Diabetic Complications n=60 (Oct 27, 2015)

Institutional Research Collaborators

Pennington Biomedical Research Center, Louisiana State University
University of California Irvine (Surgery, Biomedical Engineering, Cell Biology)
McGovern Medical School, University of Texas Health Science Center
Mercer University
School of Medicine
University at Buffalo,

SUNY

Impact & Scale

Expanding Access to Physiologic Restoration
United States Provider Network
Clinic
Educational center
Istanbul, Turkey
Baku, Azerbaijan
Beirut,Tripoli, Lebanon
Dubai, UAE
The Global Footprint When Scott launched Diabetes Relief, PIR existed in a handful of clinics. Today, Well Cell Global operates through four distinct regional brands, Diabetes Relief, Diabetes Relax, Diabetes Relief Middle East, and Diabetes Relax GCC, spanning 212+ locations across North America, the Caribbean, Eurasia, Southern Africa, and the Middle East.
That footprint is the direct result of choosing empowerment over dependency, building a licensing model that trusts local physicians to lead, rather than a corporate chain that controls from the top.

By the Numbers

212+
Locations Across
6 Continents
Multiple patents
and
patents pending
$16.8M
Federal court judgment and
permanent injunction protecting
Well Cell IP (May 2025)
380,000+
PIR Treatments Administered Globally
200+
licenses issued worldwide

for PIR®